Karuna's D-4000 supplies highly-bioavailable vitamin D3 in a convenient amount for generous supplementation.
- Not long ago, vitamin D was thought to have a singular function, to help maintain serum calcium levels by facilitating intestinal calcium absorption and helping to regulate renal excretion and bone remodeling. Modest amounts of vitamin D were known to be adequate to prevent low calcium levels and acute bone loss diseases such as rickets and osteomalacia.
- Today, not only are adequate levels of vitamin D intake for optimum bone protection being revised sharply upward, but newly identified roles for vitamin D have been discovered, indicating far wider health effects from this essential nutrient. Tissues possessing vitamin D receptors and/or expressing the enzyme for local activation of vitamin D include the immune system, skin, pancreas, prostate, colon, adrenal glands, brain, and others.
- Vitamin D appears to influence cellular differentiation and proliferation, immune system activity, insulin physiology, blood pressure regulation, and other body processes in ways never before imagined. Recent research is exploring the clinical implications of these new discoveries. The safety of high vitamin D intake has also been re-examined, with upper levels now set at a minimum of 2000 IU per day, and perhaps much higher.