The only original patented, physician recommended nutritional supplement for either men, women or children age 12 and older, who suffer from migraines. MigreLief contains ingredients proven to make a difference.
When taken daily, MigreLief helps to maintain both normal cerebrovascular tone & function and healthy mitochondrial energy reserves which are often disrupted in people who have migraines. Nutritional deficiencies, inflammation and vasospasm can independently and together contribute to migraine occurrence, frequency and intensity. MigreLief’s patented triple action formula has been recommended by headache specialist for over 2 decades.
Puracol™, MigreLief’s proprietary blend of two unique Feverfew sources, Magnesium from two sources and high dose, highly absorbable Riboflavin (Vitamin B-2) have all independently been shown to be of significant benefit to migraine sufferers.
|Magnesium (citrate and oxide)
|Riboflavin (Vitamin B2)||400mg/day|
|Puracol™ Feverfew (proprietary extract + whole leaf)||100mg/day|
Take 1 tablet twice daily.
MigreLief is designed to provide benefits within the 90 day build up period.
Continue daily use if you notice benefits.
MigreLief is drug-free. No prescription necessary.
Like most dietary supplements, use of MigreLief should be discontinued one week before surgery to reduce the risk of excessive bleeding.
Please note: Not for use during pregnancy, during lactation or by children under 2 years of age.
MigreLief (formerly MigreHealth and MigreLieve) is the original patented combination (patents 6,068,999 and 6,500,450 with 3rd patent pending) of 3 nutritional ingredients, which multiple, double-blind, placebo controlled clinical studies published in top medical journals have shown to be nutritionally beneficial to migraine sufferers.
In addition to high dose riboflavin, MigreLief contains a specific combination of two forms of magnesium. Puracol™ represents proprietary feverfew science specific to MigreLief. While extracts of feverfew can maximize certain phytochemicals found in the whole plant, like parthenolides, the extraction process can also remove other naturally occurring phytochemicals that may be required for maximum efficacy. The Puracol™ technology corrects this problem by simultaneously maximizing parthenolide levels while maintaining the full spectrum of all the other naturally occurring compounds found in the whole plant.
Research studies show that almost half of all migraine sufferers have low blood levels of Magnesium, which is critical in controlling vasospasms (the contraction and dilation of blood vessels in the brain which occurs during migraines).
Migraine sufferers also suffer mitochondrial energy deficiencies, which Riboflavin (Vitamin B2) can improve when given in high dosages.
The plant material Feverfew has been shown to reduce platelet aggregation, which can lead to vasoconstriction. All 3 ingredients have been recommended for years physicians including neurologists and top headache specialists based on the clinical studies behind them.
MigreLief combines all three of these ingredients into one convenient formula. So, with MigreLief, you need only one product (instead of three separate products), and you take only two tablets per day, versus 4 to 10 tablets per day if taken separately. Plus, MigreLief’s Puracol™ Feverfew contains high levels of parthenolides and other beneficial phyto-chemicals (natural plant compounds).
Magnesium is a nutritional supplement with numerous effects that support cerebrovascular tone. These include: 1) inhibition of platelet aggregation; 2) interference with synthesis, release, and action of inflammatory mediators; 3) direct alterations of cerebrovascular tone; 4) inhibition of vasospasm; and 5) stabilization of cell membranes. Some migraine sufferers with poor cerebrovascular tone have been found to have low brain levels of magnesium. Recommended daily dosages of magnesium typically range from 200 to 600 mg to compensate for this deficiency, far above what’s found in most multi-vitamins. Several double blind placebo controlled studies have demonstrated that oral magnesium is of nutritional benefit to migraine sufferers both adults and children. (11-16)
Riboflavin (vitamin B-2) is a precursor of flavin adenine dinucleotide (FAD). This coenzyme is an important component of the electron-transport chain. A deficiency of mitrochondrial energy reserves has been observed in some persons exhibiting poor cerebrovascular tone. This defect may theoretically be corrected by a compound such as riboflavin that improves the activity of the electron-transport chain. MigreLief provides 400mg of Riboflavin, which is significantly higher than most multi-vitamins or B-complex products. Multiple studies have demonstrated that high dose riboflavin is of nutritional benefit to both adults and children who have migraines. (17-20)
Puracol™ Feverfew is unique to Migrelief. Commonly recommended for its ability to support cerebrovascular tone, feverfew (Tanacetum Parthenium) is rich in compounds known as sesquiterpene lactones. One of the more important of these compounds may be parthenolide, which represents 85% of the sesquiterpene lactone content in feverfew. Some scientific studies indicate that while parthenolide may be important there may very well be other phytochemicals in feverfew that are as of yet unidentified and play a role in its effectiveness. Some studies of extracts of feverfew containing parthenolide yielded no significant benefits. This led researchers to believe that certain of the unidentified phytochemicals may have been left behind during the extraction process. The ideal solution would be a non extracted feverfew product that naturally contained high levels of parthenolide and kept all of the other naturally occurring phytochemicals as well. Thus Puracol Feverfew, AKESO HEALTH SCIENCE’S proprietary non extracted plant source for feverfew with high levels of naturally occurring parthenolide and other phyto-chemicals was developed. Puracol™ Feverfew is just one of the reasons for the effectiveness of MigreLief. Scientific studies have found parthenolide inhibits platelet aggregation and the release of serotonin from platelets and polymorphonuclear leukocyte granules.* It has also been shown to inhibit pro-inflammatory prostaglandin synthesis and the release of arachadonic acid. Each of these phenomena is associated with migraines. European studies have shown the benefits of feverfew on long-term cerebrovasular tone in multiple human studies. (1-10)
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.